Article
Modification of the untranslated regions of human enterovirus 71 impairs growth in a cell-specific manner.
Journal of virology - 1 Jan 2012
Kok Chee Choy, Phuektes Patchara, Bek Emily, McMinn Peter C
Abstract excerpt
Human enterovirus 71 (HEV71) is the causative agent of hand, foot, and mouth disease and associated acute neurological disease. At present, little is known about the genetic determinants of HEV71 neurovirulence. Studies of related enteroviruses have indicated that the untranslated regions (UTRs), which control virus-directed translation and replication, also exert significant influence on neurovirulence. We used...
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