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Article

Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD.

Journal of virology - 1 Aug 2007

Florez de Sessions Paola, Dobrikova Elena, Gromeier Matthias

Abstract excerpt

Both untranslated regions (UTRs) of plus-strand RNA virus genomes jointly control translation and replication of viral genomes. In the case of the Enterovirus genus of the Picornaviridae family, the 5'UTR consists of a cloverleaf-like terminus preceding the internal ribosomal entry site (IRES) and the 3' terminus is composed of a structured 3'UTR and poly(A). The IRES and poly(A) have been implicated in...

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Identifiers

PMID: 17537861
DOI: 10.1128/JVI.00321-07
PMCID: PMC1951365

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