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Article

High-affinity interaction of hnRNP A1 with conserved RNA structural elements is required for translation and replication of enterovirus 71

31 May 2013

Abstract excerpt

Human Enterovirus 71 (EV71) is an emerging pathogen of infectious disease and a serious threat to public health. Currently, there are no antivirals or vaccines to slow down or prevent EV71 infections, thus underscoring the urgency to better understand mechanisms of host-enterovirus interactions. EV71 uses a type I internal ribosome entry site (IRES) to recruit the 40S ribosomal subunit via a pathway that requires...

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PMID: 23727900
DOI: 10.4161/rna.25107

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High-affinity interaction of hnRNP A1 with conserved RNA structural elements is required for translation and replication of enterovirus 71PMID 23727900Read ↗

Stack Locally and Act Globally: A Few Nucleotides Make All the Difference in Enterovirus 71 IRES Binding hnRNAP A1 and Infectious Phenotypes: Commentary on "HnRNP A1 Alters the Structure of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation".Semantic proximity Read ↗

Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growthSemantic proximity Read ↗

Additive Promotion of Viral Internal Ribosome Entry Site-Mediated Translation by Far Upstream Element-Binding Protein 1 and an Enterovirus 71-Induced Cleavage ProductSemantic proximity Read ↗

Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection.Semantic proximity Read ↗

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry.Semantic proximity Read ↗

The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life CycleSemantic proximity Read ↗

HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and ReplicationSemantic proximity Read ↗

Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5′ untranslated region and participates in virus replicationSemantic proximity Read ↗

PolyC-Binding Protein 1 Interacts with 5′-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral ReplicationSemantic proximity Read ↗

Polypyrimidine Tract-Binding Protein Regulates Enterovirus 71 Translation Through Interaction with the Internal Ribosomal Entry SiteSemantic proximity Read ↗

Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3GSemantic proximity Read ↗

Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN ProteinSemantic proximity Read ↗

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