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Article

Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2012

Dudbridge Frank, Fletcher Olivia, Walker Kate, Johnson Nichola, Orr Nick, Dos Santos Silva Isabel, Peto Julian

Abstract excerpt

BACKGROUND: Cases with a family history are enriched for genetic risk variants, and the power of association studies can be improved by selecting cases with a family history of disease. However, in recent genome-wide association scans utilizing familial sampling, the excess relative risk for familial cases is less than predicted when compared with unselected cases. This can be explained by incomplete linkage...

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PMID: 22028405
DOI: 10.1158/1055-9965.EPI-11-0719
PMCID: PMC3272480

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