Article
Association studies using familial cases: an efficient strategy for identifying low-penetrance disease alleles.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Webb Emily L, Houlston Richard S
Abstract excerpt
Low-penetrance alleles are likely to contribute to inherited susceptibility to many complex traits. Such alleles will rarely generate multiple-case families and are therefore difficult or impossible to identify through genetic linkage analyses. The search for low-penetrance alleles has therefore...
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