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Article

Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction.

Scientific reports - 4 Mar 2026

Naderi Elnaz, Watt Gordon P, Knight Julia A, Malone Kathleen E, Lynch Charles F, John Esther M, Shu Xiang, Nguyen Tuong L, Oh Jung Hun, Woods Meghan, Liang Xiaolin, Derkach Andriy, Pike Malcolm C, Bernstein Jonine L

Abstract excerpt

Survivors of breast cancer face a substantially increased risk of developing contralateral breast cancer (CBC). We assessed whether risk prediction models for CBC are improved by integrating mammographic density (MD) and polygenic risk scores (PRS). We analyzed data from 399 European-ancestry breast cancer survivors in the WECARE Study, an international, population-based case-control study. Cases were women who...

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Identifiers

PMID: 41781474
DOI: 10.1038/s41598-026-42365-7
PMCID: PMC13077059

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UBC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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