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Polygenic scores in Familial breast cancer cases with and without pathogenic variants and the risk of contralateral breast cancer

8 Sept 2025

Abstract excerpt

Abstract Background Polygenic risk scores (PRS) are not yet standard in clinical risk assessments for familial breast cancer in Sweden. This study evaluated the distribution and impact of an established PRS (PRS313) in women undergoing clinical sequencing for hereditary breast cancer. Findings We integrated PRS313 into a hereditary breast cancer gene panel used in clinical practice and calculated scores for 262...

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PMID: 40922009
DOI: 10.1186/s13058-025-02107-5

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