Article
Clustering of known low and moderate risk alleles rather than a novel recessive high-risk gene in non-BRCA1/2 sib trios affected with breast cancer.
International journal of cancer - 15 Nov 2020
Hilbers Florentine S, van 't Hof Peter J, Meijers Caro M, Mei Hailiang, Michailidou Kyriaki, Dennis Joe, Hogervorst Frans B L, Nederlof Petra M, van Asperen Christi J, Devilee Peter
Abstract excerpt
Breast cancer risk is approximately twice as high in first-degree relatives of female breast cancer cases than in women in the general population. Less than half of this risk can be attributed to the currently known genetic risk factors. Recessive risk alleles represent a relatively underexplored explanation for the remainder of familial risk. To address this, we selected 19 non-BRCA1/2 breast cancer families in...
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