Article
Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2008
Zhang Han-Ting, Huang Ying, Masood Anbrin, Stolinski Lisa R, Li Yunfeng, Zhang Lei, Dlaboga Daniel, Jin S-L Catherine, Conti Marco, O'Donnell James M
Abstract excerpt
Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and plays a critical role in controlling its intracellular concentration, has been implicated in depression- and anxiety-like behaviors. However, the functions of the four PDE4 subfamilies (PDE4A, PDE4B, PDE4C, and PDE4D) remain largely unknown. In animal tests sensitive to anxiolytics, antidepressants, memory enhancers, or...
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