Article
Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.
BMC neuroscience - 2 Dec 2017
Campbell Susan L, van Groen Thomas, Kadish Inga, Smoot Lisa High Mitchell, Bolger Graeme B
Abstract excerpt
BACKGROUND: PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DISC1 protein, implicated in neural development and behavioral disorders. The cellular functions of PDE4B1 have been...
Topics
- Animals
- Anxiety
- Association Learning
- Conditioning, Psychological
- Cyclic AMP Response Element-Binding Protein
- Cyclic Nucleotide Phosphodiesterases, Type 4
- Depression
- Fear
- Female
- Hippocampus
- Isoenzymes
- Long-Term Potentiation
- Male