Article
Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2008
Huang Xi, Goudy Steven L, Ketova Tatiana, Litingtung Ying, Chiang Chin
Abstract excerpt
Palatogenesis depends on appropriate growth, elevation, and fusion of the palatal shelves and aberration in these processes can lead to palatal clefting. We observed a high incidence of palate clefting in mice deficient in Gli3, known for its role as a repressor in the absence of Shh signaling. In contrast with several current mouse models of cleft palate, Meckel's cartilage extension, cranial neural crest...
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