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Article

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

PloS one - 1 Jan 2017

Hasegawa Daigo, Ochiai-Shino Hiromi, Onodera Shoko, Nakamura Takashi, Saito Akiko, Onda Takeshi, Watanabe Katsuhito, Nishimura Ken, Ohtaka Manami, Nakanishi Mahito, Kosaki Kenjiro, Yamaguchi Akira, Shibahara Takahiko, Azuma Toshifumi

Abstract excerpt

Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. Causative mutations in several genes associated with the sonic hedgehog (SHH) signaling pathway, including PTCH1, have been identified in Gorlin syndrome patients. However, no definitive genotype-phenotype correlations are evident in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29088246
DOI: 10.1371/journal.pone.0186879
PMCID: PMC5663396

Genes

SHH
GLI1
IHH
PTCH1
BMP4
BMP6
GLI2
GLI3
HHAT
SAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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