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Article

GSK-3 is a master regulator of neural progenitor homeostasis.

Nature neuroscience - 1 Nov 2009

Kim Woo-Yang, Wang Xinshuo, Wu Yaohong, Doble Bradley W, Patel Satish, Woodgett James R, Snider William D

Abstract excerpt

The development of the brain requires the exquisite coordination of progenitor proliferation and differentiation to achieve complex circuit assembly. It has been suggested that glycogen synthase kinase 3 (GSK-3) acts as an integrating molecule for multiple proliferation and differentiation signals because of its essential role in the RTK, Wnt and Shh signaling pathways. We created conditional mutations that...

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Identifiers

PMID: 19801986
DOI: 10.1038/nn.2408
PMCID: PMC5328673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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