Article

GSK3β Rephosphorylation Rescues ALPL Deficiency Induced-impairment of Odontoblastic Differentiation of DPSCs

2020-12-10

Abstract excerpt

<h4>Background: </h4> Premature exfoliation of deciduous teeth is a common manifestation in childhood patients with Hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of cementum, dentin and alveolar bone have been proposed to be the main reasons for the exfoliation of teeth, while the extraordinarily complex intracellular mechanisms remain elusive. Dental pulp stem...

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Literature Corpus work: b13150ae-0904-5615-ad14-3e99dc6f7ec8
DOI: 10.21203/rs.3.rs-122504/v1

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