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Article

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.

Blood - 14 Oct 2010

Walters Kevin B, Green Julie M, Surfus Jill C, Yoo Sa Kan, Huttenlocher Anna

Abstract excerpt

CXCR4 is a G protein-coupled chemokine receptor that has been implicated in the pathogenesis of primary immunodeficiency disorders and cancer. Autosomal dominant gain-of-function truncations of CXCR4 are associated with warts, hypo-gammaglobulinemia, infections, and myelokathexis (WHIM) syndrome,...

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Share to Agammaglobulinemia
Share to Chemokine CXCL12
Share to Chemotaxis, Leukocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Immunologic Deficiency Syndromes

Share to Neutropenia

Share to Neutrophils

Share to Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 20592249
DOI: 10.1182/blood-2010-03-276972
PMCID: PMC2974588

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20592249-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.PMID 20592249Read ↗

Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue.Semantic proximity Read ↗

Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.Semantic proximity Read ↗

Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients.Semantic proximity Read ↗

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.Semantic proximity Read ↗

WHIM syndrome: a genetic disorder of leukocyte trafficking.Semantic proximity Read ↗

A CRISPR/Cas9 vector system for neutrophil-specific gene disruption in zebrafishSemantic proximity Read ↗

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.Semantic proximity Read ↗

Stromal-derived factor-1 abolishes constitutive apoptosis of WHIM syndrome neutrophils harbouring a truncating CXCR4 mutation.Semantic proximity Read ↗

Biallelic CXCR2 loss-of-function mutations define a distinct congenital neutropenia entitySemantic proximity Read ↗

CXCL12/CXCR4-Axis Dysfunctions: Markers of the Rare Immunodeficiency Disorder WHIM SyndromeSemantic proximity Read ↗

Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome.Semantic proximity Read ↗

CXCL12/CXCR4-axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome.Semantic proximity Read ↗

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