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Article

Aristolochic acid as a probable human cancer hazard in herbal remedies: a review

1 Jul 2002

Abstract excerpt

The old herbal drug aristolochic acid (AA), derived from Aristolochia spp., has been associated with the development of a novel nephropathy, designated aristolochic acid nephropathy (AAN), and urothelial cancer in AAN patients. There is clear evidence that the major components of the plant extract AA, aristolochic acid I (AAI) and aristolochic acid II (AAII), both nitrophenanthrene carboxylic acids, are genotoxic...

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Share to Drug-Induced Hepatotoxicity and Protection
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 12110620
DOI: 10.1093/mutage/17.4.265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aristolochic acid as a probable human cancer hazard in herbal remedies: a reviewPMID 12110620Read ↗

DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial CancerSemantic proximity Read ↗

Enzymes Metabolizing Aristolochic Acid and their Contribution to the Development of Aristolochic Acid Nephropathy and Urothelial CancerSemantic proximity Read ↗

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Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid NephropathySemantic proximity Read ↗

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Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models.Semantic proximity Read ↗

Aristolochic acid suppresses DNA repair and triggers oxidative DNA damage in human kidney proximal tubular cellsSemantic proximity Read ↗

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathySemantic proximity Read ↗

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