Activating mutation of the Ha-ras gene in chemically induced tumors of the hamster cheek pouch.

doi:10.1002/mc.2940050405

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Article

Activating mutation of the Ha-ras gene in chemically induced tumors of the hamster cheek pouch.

Molecular carcinogenesis - 1 Jan 1992

Gimenez-Conti I B, Bianchi A B, Stockman S L, Conti C J, Slaga T J

Abstract excerpt

The presence of an activating mutation in the Ha-ras gene in hamster cheek pouch tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) complete carcinogenesis was investigated. The normal sequence of a fragment of genomic DNA encompassing codon 61 of the Ha-ras gene was amplified by the polymerase chain reaction using primers designed for a highly conserved region of the mouse Ha-ras-1 gene. The sequence of the...

Topics

9,10-Dimethyl-1,2-benzanthracene
Alleles
Amino Acid Sequence
Animals
Base Sequence
Carcinoma, Squamous Cell
Cricetinae
DNA Mutational Analysis
Genes, ras
Humans
Mesocricetus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mouth Neoplasms

Mutagenesis

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 1497802
DOI: 10.1002/mc.2940050405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1497802-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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