Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice.

doi:10.1016/0304-3835(91)90178-k

Back to search

Article

Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice.

Cancer letters - 1 Aug 1991

Schmeiser H H, Scherf H R, Wiessler M

Abstract excerpt

The plant extract aristolochic acid, which consists mainly of aristolochic acid I (AAI) and aristolochic acid II (AAII), induces tumors in rats and mice. Thin-tissue sections of rat tumors induced by AAI and of mouse tumors induced by aristolochic acid, were analyzed for c-Ha-ras mutations in cod...

Topics

Animals
Aristolochic Acids
Base Sequence
Codon
DNA, Neoplasm
Female
Genes, ras
Male
Mice
Molecular Sequence Data
Mutagens
Mutation
Neoplasms, Experimental
Phenanthrenes
Polymerase Chain Reaction
Rats
Rats, Inbred Strains

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.