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Article

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Blood - 15 Dec 2011

Huang Gang, Zhao Xinghui, Wang Lan, Elf Shannon, Xu Hao, Zhao Xinyang, Sashida Goro, Zhang Yue, Liu Yan, Lee Jennifer, Menendez Silvia, Yang Youyang, Yan Xiaomei, Zhang Pu, Tenen Daniel G, Osato Motomi, Hsieh James J-D, Nimer Stephen D

Abstract excerpt

The mixed-lineage leukemia (MLL) H3K4 methyltransferase protein, and the heterodimeric RUNX1/CBFβ transcription factor complex, are critical for definitive and adult hematopoiesis, and both are frequently targeted in human acute leukemia. We identified a physical and functional interaction between RUNX1 (AML1) and MLL and show that both are required to maintain the histone lysine 4 trimethyl mark (H3K4me3) at 2...

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Share to Chromatin Immunoprecipitation
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid

Share to Methylation

Share to Myelodysplastic Syndromes

Share to Myeloid-Lymphoid Leukemia Protein

Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 22012064
DOI: 10.1182/blood-2010-11-317909
PMCID: PMC3242717

Genes

RUNX1

Provenance

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Related research

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The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.PMID 22012064Read ↗

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