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Article

Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.

Journal of cellular biochemistry - 1 Nov 2005

Li Xiangen, Vradii Diana, Gutierrez Soraya, Lian Jane B, van Wijnen Andre J, Stein Janet L, Stein Gary S, Javed Amjad

Abstract excerpt

Many types of acute myelogenous leukemia involve chromosomal translocations that target the C-terminus of Runx1/AML1 transcription factor, a master regulator of hematopoiesis. The C-terminus of Runx1/AML1 that includes the nuclear matrix targeting signal (NMTS) is essential for embryonic development, hematopoiesis, and target gene regulation. During the onset and normal progression of hematopoiesis, several...

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Identifiers

PMID: 16149049
DOI: 10.1002/jcb.20548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.PMID 16149049Read ↗

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Semantic proximity Read ↗

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A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene.Semantic proximity Read ↗

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Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.Semantic proximity Read ↗

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1Semantic proximity Read ↗

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.Semantic proximity Read ↗

Identification of a monopartite sequence in PU.1 essential for nuclear import, DNA-binding and transcription of myeloid-specific genes.Semantic proximity Read ↗

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Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.Semantic proximity Read ↗

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.Semantic proximity Read ↗

The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.Semantic proximity Read ↗

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