Article
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.
Blood - 13 Mar 2014
Zhao Xinghui, Chen Aili, Yan Xiaomei, Zhang Yue, He Fuhong, Hayashi Yoshihiro, Dong Yunzhu, Rao Yalan, Li Bo, Conway Rajeana M, Maiques-Diaz Alba, Elf Shannon E, Huang Nuomin, Zuber Johannes, Xiao Zhijian, Tse William, Tenen Daniel G, Wang Qianfei, Chen Wei, Mulloy James C, Nimer Stephen D, Huang Gang
Abstract excerpt
RUNX1/CBFβ (core binding factor [CBF]) is a heterodimeric transcription factor complex that is frequently involved in chromosomal translocations, point mutations, or deletions in acute leukemia. The mixed lineage leukemia (MLL) gene is also frequently involved in chromosomal translocations or partial tandem duplication in acute leukemia. The MLL protein interacts with RUNX1 and prevents RUNX1 from...
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