Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Epigenetic Programs in MLL-Rearranged Leukemias

7 Dec 2011

Abstract excerpt

Rearrangements of the Mixed-Lineage Leukemia (MLL) gene are found in > 70% of infant leukemia, ~ 10% of adult acute myelogenous leukemia (AML), and many cases of secondary acute leukemias. The presence of an MLL rearrangement generally confers a poor prognosis. There are more than 60 known fusion partners of MLL having some correlation with disease phenotype and prognosis. The most common fusion proteins induce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22160057
DOI: 10.1182/asheducation-2011.1.354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Epigenetic Programs in MLL-Rearranged LeukemiasPMID 22160057Read ↗

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological InterventionsSemantic proximity Read ↗

The molecular biology of mixed lineage leukemiaSemantic proximity Read ↗

In focus: MLL-rearranged leukemia.Semantic proximity Read ↗

MLL-Rearranged Leukemias—An Update on Science and Clinical ApproachesSemantic proximity Read ↗

Novel therapeutic strategies for MLL-rearranged leukemias.Semantic proximity Read ↗

Molecular and Epigenetic Mechanisms of MLL in Human LeukemogenesisSemantic proximity Read ↗

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Semantic proximity Read ↗

The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemiaSemantic proximity Read ↗

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genomeSemantic proximity Read ↗

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibitionSemantic proximity Read ↗

An MLL-dependent network sustains hematopoiesisSemantic proximity Read ↗

MLL: how complex does it get?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.