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Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

2022-12-19

Abstract excerpt

Our understanding of acute leukemia pathology is heavily dependent on 11q23 chromosomal translocations involving the mixed lineage leukemia-1 (MLL1) gene, a key player in histone H3 lysine 4 (H3K4) methylation. These translocations result in distinct MLL1-fusion (MLL1F) proteins that are thought to drive leukemogenesis. However, the mechanism behind increased H3K4 trimethylation in MLL1F-leukemic stem cells (MLL1F...

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Literature Corpus work
8af4d6c9-cb38-5024-a71b-a6972bbc02d6
DOI
10.1101/2022.12.16.520790
Open publication

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Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point MutationDOI 10.1101/2022.12.16.520790
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