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Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia

1 Dec 2022

Abstract excerpt

The dysregulation of developmental and stem cell-associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cases harbor an NPM1 mutation (NPM1c), which encodes for an oncoprotein mislocalized from the nucleolus to the cytoplasm. How NPM1c expression in hematopoietic cells leads...

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PMID: 36455613
DOI: 10.1158/2159-8290.cd-22-0366

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