Article
N-ras mutation detection by pyrosequencing in adult patients with acute myeloid leukemia at a single institution.
Annals of laboratory medicine - 1 May 2013
Jeong Ji Hun, Park Soon Ho, Park Mi Jung, Kim Moon Jin, Kim Kyung Hee, Park Pil Whan, Seo Yiel Hea, Lee Jae Hoon, Park Jinny, Hong Junshik, Ahn Jeong Yeal
Abstract excerpt
BACKGROUND: N-ras mutations are one of the most commonly detected abnormalities of myeloid origin. N-ras mutations result in a constitutively active N-ras protein that induces uncontrolled cell proliferation and inhibits apoptosis. We analyzed N-ras mutations in adult patients with AML at a particular institution and compared pyrosequencing analysis with a direct sequencing method for the detection of N-ras...
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