Article
Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia.
Breast cancer research and treatment - 1 Jul 1998
Chu L L, Rutteman G R, Kong J M, Ghahremani M, Schmeing M, Misdorp W, van Garderen E, Pelletier J
Abstract excerpt
To determine whether canine malignancies share common genetic lesions with their human counterparts, and are thus potentially interesting model systems in which to pose questions regarding tumor etiology and progression, we have elucidated the entire exon/intron structure of the canine p53 gene. A search for p53 gene abnormalities in mammary tumor tissue was undertaken utilizing single strand conformation...
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