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Article

Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line.

Biochemical and biophysical research communications - 4 Nov 2011

Sung Hye Youn, Choi Eun Nam, Ahn Jo Sangmee, Oh Seikwan, Ahn Jung-Hyuck

Abstract excerpt

The Swedish mutation of amyloid precursor protein (APP-sw) has been reported to dramatically increase beta amyloid production through aberrant cleavage at the beta secretase site, causing early-onset Alzheimer's disease (AD). DNA methylation has been reported to be associated with AD pathogenesis, but the underlying molecular mechanism of APP-sw-mediated epigenetic alterations in AD pathogenesis remains largely...

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Source

Identifiers

PMID: 22001921
DOI: 10.1016/j.bbrc.2011.09.136

Genes

APP
CTIF
DDR2
NXT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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