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Regulation of gene expression by the APP family in the adult cerebral cortex

7 Jan 2022

Abstract excerpt

Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer's disease. APP has two homologs, amyloid precursor-like protein 1 and 2 (APLP1 and APLP2), and they have functional redundancy. APP intracellular c-terminal domain (AICD), produced by sequential α- or β- and γ-secretase cleavages, is thought to control gene expression, similarly as the ICD of Notch. To investigate the...

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PMID: 34997052
DOI: 10.1038/s41598-021-04027-8

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