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Article

Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease.

BMB reports - 1 Oct 2010

Shin Jongyeon, Yu Saet-Byeol, Yu Un Young, Jo Sangmee Ahn, Ahn Jung-Hyuck

Abstract excerpt

The Swedish mutation (K595N/M596L) of amyloid precursor protein (APP-swe) has been known to increase abnormal cleavage of cellular APP by Beta-secretase (BACE), which causes tau protein hyperphosphorylation and early-onset Alzheimer's disease (AD). Here, we analyzed the effect of APP-swe in globa...

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Source

Identifiers

PMID: 21034535
DOI: 10.5483/BMBRep.2010.43.10.704

Genes

APP
CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21034535-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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