LncRNA Loc646329 modulates Alzheimer's disease-related phenotypes through the miR-150/WNT/β-catenin axis in cellular and APP/PS1 mouse models.

doi:10.1007/s11033-026-12734-6

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Article

LncRNA Loc646329 modulates Alzheimer's disease-related phenotypes through the miR-150/WNT/β-catenin axis in cellular and APP/PS1 mouse models.

Molecular biology reports - 18 Sept 2026

Abdi Kimia, Amiri Mahan, Asadalizadeh Mahya, Khanmirzaei Amir, Javanmard Amir-Reza, Rezaeimirghaed Omidvar, Hajiesmaeili Mohammadreza, Ghaderian Sayyed Mohammad Hossein

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, neuronal apoptosis, and amyloid‑β (Aβ) deposition. Dysregulation of the WNT/β‑catenin signaling pathway contributes to AD pathogenesis, yet the upstream regulatory mechanisms, particularly those involving long non‑coding RNAs (lncRNAs), remain unclear. This study investigated the neuroprotective...

Read the complete abstract on PubMed

Topics

MicroRNAs
Alzheimer Disease
Animals
Wnt Signaling Pathway
Humans
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Models, Animal

beta Catenin

Apoptosis

RNA, Long Noncoding

Mice, Transgenic

Amyloid beta-Protein Precursor

Amyloid beta-Peptides

Male

Presenilin-1

Phenotype

Neurons

Hippocampus

Source

Open in PubMed

Identifiers

PMID: 42758358
DOI: 10.1007/s11033-026-12734-6

Genes

APP
AGO2
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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