Article
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
American journal of human genetics - 1 Jun 2006
Theuns Jessie, Brouwers Nathalie, Engelborghs Sebastiaan, Sleegers Kristel, Bogaerts Veerle, Corsmit Ellen, De Pooter Tim, van Duijn Cornelia M, De Deyn Peter P, Van Broeckhoven Christine
Abstract excerpt
Genetic variations in promoter sequences that alter gene expression play a prominent role in increasing susceptibility to complex diseases. Also, expression levels of APP are essentially regulated by its core promoter and 5' upstream regulatory region and correlate with amyloid beta levels in Alzheimer disease (AD) brains. Here, we systematically sequenced the proximal promoter (-766/+204) and two functional...
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