Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease

15 Sept 2022

Abstract excerpt

BACKGROUND: Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progression of these diseases. Particularly, hypomethylation of the amyloid precursor protein gene (APP) has been reported in patients with AD. METHODS: In this study, we used catalytically inactivated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36109806
DOI: 10.1186/s40035-022-00314-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s diseasePMID 36109806Read ↗

CRISPR/Cas9 gene editing: New hope for Alzheimer's disease therapeuticsSemantic proximity Read ↗

Applying gene-editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer's disease.Semantic proximity Read ↗

Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease.Semantic proximity Read ↗

A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathwaySemantic proximity Read ↗

Targeted DNA methylation of neurodegenerative disease genes via homology directed repairSemantic proximity Read ↗

Application of CRISPR/Cas9 in the management of Alzheimer’s disease and Parkinson’s disease: a reviewSemantic proximity Read ↗

Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line.Semantic proximity Read ↗

Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease.Semantic proximity Read ↗

Precise and efficient insertion of A673T mutation in APP gene using MSYMSemantic proximity Read ↗

The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer's DiseaseSemantic proximity Read ↗

Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitroSemantic proximity Read ↗

CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.