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Targeted DNA methylation of neurodegenerative disease genes via homology directed repair

12 Oct 2019

Abstract excerpt

DNA methyltransferases (DNMTs) are thought to be involved in the cellular response to DNA damage, thus linking DNA repair mechanisms with DNA methylation. In this study we present Homology Assisted Repair Dependent Epigenetic eNgineering (HARDEN), a novel method of targeted DNA methylation that utilizes endogenous DNA double strand break repair pathways. This method allows for stable targeted DNA methylation...

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PMID: 31680172
DOI: 10.1093/nar/gkz979

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