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Article

Genome-wide analysis of DNA methylation in an APP/PS1 mouse model of Alzheimer's disease.

Acta neurologica Belgica - 1 Sept 2014

Cong Lin, Jia Jianping, Qin Wei, Ren Yan, Sun Yongxin

Abstract excerpt

To investigate aberrant genome-wide CpG methylation patterns in cortex brain tissue of APP/PS1 mice and as compared to controls, which allows for identification of novel disease-associated genes. This study investigates the genome-wide DNA methylation profiles of the cortex from APP/PS1 transgenic mice and control mice using the Roche NimbleGen chip platform. Functional analysis was then conducted by Ingenuity...

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PMID: 24347181
DOI: 10.1007/s13760-013-0267-6

Genes

APP

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