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Article

Creation of aggregation-defective α-synuclein variants by engineering the sequence connecting β-strand-forming domains.

Chembiochem : a European journal of chemical biology - 25 Nov 2011

Hernandez Michael, Golbert Sofia, Zhang Li Guo, Kim Jin Ryoun

Abstract excerpt

The aggregation of α-synuclein (αS), which is implicated in the pathology of Parkinson's disease, produces fibrils in which layers of parallel, in-register β-sheet-loop-β-sheets are formed. The effects of sequence variation in the loop-forming region (referred to as the linker region) on αS aggregation have yet to be systematically studied. In the study described here, we created and characterized αS variants...

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PMID: 21998035
DOI: 10.1002/cbic.201100430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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