Article

Liquid–liquid phase separation of α-synuclein is highly sensitive to sequence complexity

2023-08-03

Abstract excerpt

The Parkinson’s-associated protein α-synuclein (α-syn) can undergo liquid–liquid phase separation (LLPS), which typically leads to the formation of amyloid fibrils. The coincidence of LLPS and amyloid formation has complicated the identification of the molecular determinants unique to LLPS of α-syn. Moreover, the lack of strategies to selectively perturb LLPS makes it difficult to dissect the biological roles spec...

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Literature Corpus work: e89755fe-9764-59a0-adaa-7e6a20ab87b8
DOI: 10.1101/2023.08.03.551831

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