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Article

Liquid-liquid phase separation of α-synuclein is highly sensitive to sequence complexity.

Protein science : a publication of the Protein Society - 1 Apr 2024

Mahapatra Anindita, Newberry Robert W

Abstract excerpt

The Parkinson's-associated protein α-synuclein (α-syn) can undergo liquid-liquid phase separation (LLPS), which typically leads to the formation of amyloid fibrils. The coincidence of LLPS and amyloid formation has complicated the identification of the molecular determinants unique to LLPS of α-syn. Moreover, the lack of strategies to selectively perturb LLPS makes it difficult to dissect the biological roles...

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PMID: 38511533
DOI: 10.1002/pro.4951
PMCID: PMC10955625

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