Article
Mixed-effects logistic approach for association following linkage scan for complex disorders.
Annals of human genetics - 1 Mar 2007
Xu H, Shete S
Abstract excerpt
An association study to identify possible causal single nucleotide polymorphisms following linkage scanning is a popular approach for the genetic dissection of complex disorders. However, in association studies cases and controls are assumed to be independent, i.e., genetically unrelated. Choosing a single affected individual per family is statistically inefficient and leads to a loss of power. On the other hand,...
Topics
- Algorithms
- Case-Control Studies
- Computer Simulation
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Genetics, Medical
- Humans
- Logistic Models
- Male
- Models, Genetic