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Article

Mixed modelling to characterize genotype-phenotype associations.

Statistics in medicine - 15 Mar 2005

Foulkes A S, Reilly M, Zhou L, Wolfe M, Rader D J

Abstract excerpt

We propose using mixed effects models to characterize the association between multiple gene polymorphisms, environmental factors and measures of disease progression. Characterizing high-order gene-gene and gene-environment interactions presents an analytic challenge due to the large number of candidate genes and the complex, undescribed interactions among them. Several approaches have been proposed recently to...

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PMID: 15696502
DOI: 10.1002/sim.1965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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