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Article

Identifying pleiotropic genes in genome-wide association studies from related subjects using the linear mixed model and Fisher combination function.

BMC bioinformatics - 24 Aug 2017

Yang James J, Williams L Keoki, Buu Anne

Abstract excerpt

BACKGROUND: A multivariate genome-wide association test is proposed for analyzing data on multivariate quantitative phenotypes collected from related subjects. The proposed method is a two-step approach. The first step models the association between the genotype and marginal phenotype using a linear mixed model. The second step uses the correlation between residuals of the linear mixed model to estimate the null...

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Identifiers

PMID: 28836938
DOI: 10.1186/s12859-017-1791-9
PMCID: PMC5571642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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