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Article

Gene set analysis: A step-by-step guide.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2015

Mooney Michael A, Wilmot Beth

Abstract excerpt

To maximize the potential of genome-wide association studies, many researchers are performing secondary analyses to identify sets of genes jointly associated with the trait of interest. Although methods for gene-set analyses (GSA), also called pathway analyses, have been around for more than a decade, the field is still evolving. There are numerous algorithms available for testing the cumulative effect of...

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PMID: 26059482
DOI: 10.1002/ajmg.b.32328
PMCID: PMC4638147

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