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Article

A Comparison Study of Fixed and Mixed Effect Models for Gene Level Association Studies of Complex Traits.

Genetic epidemiology - 1 Dec 2016

Fan Ruzong, Chiu Chi-Yang, Jung Jeesun, Weeks Daniel E, Wilson Alexander F, Bailey-Wilson Joan E, Amos Christopher I, Chen Zhen, Mills James L, Xiong Momiao

Abstract excerpt

In association studies of complex traits, fixed-effect regression models are usually used to test for association between traits and major gene loci. In recent years, variance-component tests based on mixed models were developed for region-based genetic variant association tests. In the mixed models, the association is tested by a null hypothesis of zero variance via a sequence kernel association test (SKAT), its...

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Identifiers

PMID: 27374056
DOI: 10.1002/gepi.21984
PMCID: PMC5567849

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