Article
A mixed two-stage method for detecting interactions in genomewide association studies.
Journal of theoretical biology - 21 Feb 2010
Zuo Yijun, Kang Guolian
Abstract excerpt
Genomewide association studies (GWAS) are being conducted to unravel the genetic etiology of complex diseases, in which complex epistasis may play an important role. One-stage method in which interactions are tested using all samples at one time may be computationally problematic, may have low power as the number of markers tested increases and may not be cost-efficient. A common two-stage method may be a...
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