Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD4+ T Lymphocytes with follicular helper phenotype (T(FH)) in patients with SH2D1A deficiency (XLP).

Clinical immunology (Orlando, Fla.) - 1 Dec 2011

Coraglia Ana, Felippo Martha, Schierloh Pablo, Malbran Alejandro, de Bracco María M de E

Abstract excerpt

Peripheral blood mononuclear cells with T(FH) phenotype from two asymptomatic XLP patients were studied. Normal/high numbers of CXCR5+, CD4+ T cells coexpressing PD-1 were demonstrated. Peripheral blood mononuclear cells (PBMC) from these patients responded to sub-optimal PHA/IL-2 stimulation upregulating ICOS and CD40L and increasing intracellular expression of IL-10, IL-21 and IL-4 by CD4+ T(FH) cells. However...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD40 Ligand
Share to Immunoglobulins, Intravenous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inducible T-Cell Co-Stimulator Protein

Share to Interleukin-2

Share to Lymphoproliferative Disorders

Share to Phytohemagglutinins

Share to Signaling Lymphocytic Activation Molecule Associated Protein

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 21996454
DOI: 10.1016/j.clim.2011.09.007

Genes

ICOS
CXCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD4+ T Lymphocytes with follicular helper phenotype (T(FH)) in patients with SH2D1A deficiency (XLP).PMID 21996454Read ↗

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.Semantic proximity Read ↗

Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members.Semantic proximity Read ↗

Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production.Semantic proximity Read ↗

Differentiation of human T follicular helper cells <i>in vitro</i> requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2Semantic proximity Read ↗

T Cell Abnormalities in X-Linked Agammaglobulinaemia: an Updated Review.Semantic proximity Read ↗

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.Semantic proximity Read ↗

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures.Semantic proximity Read ↗

Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sjögren's syndrome.Semantic proximity Read ↗

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.Semantic proximity Read ↗

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.Semantic proximity Read ↗

OMIP-017: human CD4(+) helper T-cell subsets including follicular helper cells.Semantic proximity Read ↗

Distinct phenotypic subpopulations of circulating CD4+CXCR5+ follicular helper T cells in children with active IgA vasculitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.