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Article

Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sjögren's syndrome.

Journal of autoimmunity - 1 Jun 2014

Gong Ya-Zhuo, Nititham Joanne, Taylor Kim, Miceli-Richard Corinne, Sordet Christelle, Wachsmann Dominique, Bahram Siamak, Georgel Philippe, Criswell Lindsey A, Sibilia Jean, Mariette Xavier, Alsaleh Ghada, Gottenberg Jacques-Eric

Abstract excerpt

Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, secrete IL-21 whose augmented secretion is a hallmark of several autoimmune diseases. To decipher the cellular and molecular interactions occurring in salivary glands of patients suffering from primary Sjögren's syndrome (pSS), we investigated whether salivary gland epithelial cells (SGECs)...

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Identifiers

PMID: 24411167
DOI: 10.1016/j.jaut.2013.11.003

Genes

CXCR5
ICOS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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