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Article

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.

The Journal of experimental medicine - 9 Feb 2015

Weber Jan P, Fuhrmann Franziska, Feist Randi K, Lahmann Annette, Al Baz Maysun S, Gentz Lea-Jean, Vu Van Dana, Mages Hans W, Haftmann Claudia, Riedel René, Grün Joachim R, Schuh Wolfgang, Kroczek Richard A, Radbruch Andreas, Mashreghi Mir-Farzin, Hutloff Andreas

Abstract excerpt

The co-stimulators ICOS (inducible T cell co-stimulator) and CD28 are both important for T follicular helper (TFH) cells, yet their individual contributions are unclear. Here, we show that each molecule plays an exclusive role at different stages of TFH cell development. While CD28 regulated early expression of the master transcription factor Bcl-6, ICOS co-stimulation was essential to maintain the phenotype by...

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Share to CD28 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inducible T-Cell Co-Stimulator Protein

Share to Kruppel-Like Transcription Factors

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Source

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Identifiers

PMID: 25646266
DOI: 10.1084/jem.20141432
PMCID: PMC4322049

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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