Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.

doi:10.1182/blood-2014-03-563445

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Article

Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.

Blood - 30 Oct 2014

Audia Sylvain, Rossato Marzia, Santegoets Kim, Spijkers Sanne, Wichers Catharina, Bekker Cornelis, Bloem Andries, Boon Louis, Flinsenberg Thijs, Compeer Ewoud, van den Broek Theo, Facy Olivier, Ortega-Deballon Pablo, Berthier Sabine, Leguy-Seguin Vanessa, Martin Laurent, Ciudad Marion, Samson Maxime, Trad Malika, Lorcerie Bernard, Janikashvili Nona, Saas Philippe, Bonnotte Bernard, Radstake Timothy R D J

Abstract excerpt

Antiplatelet-antibody-producing B cells play a key role in immune thrombocytopenia (ITP) pathogenesis; however, little is known about T-cell dysregulations that support B-cell differentiation. During the past decade, T follicular helper cells (TFHs) have been characterized as the main T-cell subset within secondary lymphoid organs that promotes B-cell differentiation leading to antibody class-switch recombination...

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PMID: 25232056
DOI: 10.1182/blood-2014-03-563445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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