Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Functional variability of rhesus macaque (Macaca mulatta) NAT2 gene for drug-metabolising arylamine N-acetyltransferase 2.

Biochemical pharmacology - 1 Jun 2021

Boukouvala Sotiria, Drakomathioulaki Nafsika, Papanikolaou Georgia, Tsirka Theodora, Veyssière Charlotte, Sabbagh Audrey, Crouau-Roy Brigitte, Fakis Giannoulis

Abstract excerpt

Human NAT2 is a polymorphic pharmacogene encoding for N-acetyltransferase 2, a hepatic enzyme active towards arylamine and arylhydrazine drugs, including the anti-tubercular antibiotic isoniazid. The isoenzyme also modulates susceptibility to chemical carcinogenesis, particularly of the bladder. Human NAT2 represents an ideal model for anthropological investigations into the demographic adaptation of worldwide...

Topics

Amino Acid Sequence
Animals
Antitubercular Agents
Arylamine N-Acetyltransferase
Genetic Variation
Humans
Isoniazid
Macaca mulatta
Polymorphism, Genetic
Protein Structure, Secondary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Source

Identifiers

PMID: 33831395
DOI: 10.1016/j.bcp.2021.114545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional variability of rhesus macaque (Macaca mulatta) NAT2 gene for drug-metabolising arylamine N-acetyltransferase 2.PMID 33831395Read ↗

Polymorphism p.Val231Ile alters substrate selectivity of drug-metabolizing arylamine N-acetyltransferase 2 (NAT2) isoenzyme of rhesus macaque and human.Semantic proximity Read ↗

Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.Semantic proximity Read ↗

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure.Semantic proximity Read ↗

Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene.Semantic proximity Read ↗

Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity.Semantic proximity Read ↗

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.Semantic proximity Read ↗

Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey.Semantic proximity Read ↗

Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations.Semantic proximity Read ↗

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review.Semantic proximity Read ↗

Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis.Semantic proximity Read ↗

Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.