Article
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.
Archives of biochemistry and biophysics - 15 Feb 1993
Vatsis K P, Weber W W
Abstract excerpt
The human N-acetylation polymorphism is a genetic trait phenotypically reflected by differences in N-acetyltransferase (NAT) activity with therapeutic agents (rapid and slow acetylation), but a genetic invariability in N-acetylation of some arylamine drugs is also known. There are two highly similar human NAT genes: NAT1 is thought to encode a genetically invariant protein, whereas NAT2 has conclusively been...
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