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Article

The HIV-1 Integrase Monomer Induces a Specific Interaction with LTR DNA for Concerted Integration

12 Oct 2011

Abstract excerpt

The assembly mechanism for the human immunodeficiency virus type 1 (HIV) synaptic complex (SC) capable of concerted integration is unknown. Molecular and structural studies have established that the HIV SC and prototype foamy virus (PFV) intasome contain a tetramer of integrase (IN) that catalyzes concerted integration. HIV IN purified in the presence of 1 mM EDTA and 10 mM MgSO(4) was predominately a monomer. IN...

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PMID: 21992419
DOI: 10.1021/bi201247f

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